Table 1. Characteristics of GAD 65-specific TCR transgenic mice: 286–300 and 206–220 TCR transgenic lines.

GAD 286–300 and 206–220 TCR transgenic NOD mice do not develop diabetes.

Transgenic T cells respond well to cognate peptide/MHC stimulation.

Transgenic T cells escape thymic negative selection by expressing a second TCR α chain and down-regulating the introduced TCR transgenes.

Transgenic T cells express low levels of IFN-γ.

Transgenic T cells protect against transfer of diabetes.