Table 2. Chemotherapy regimens.
Regimens | Drugs | Doses, mg/m2/day | Schedules | Total doses, mg/m2 |
---|---|---|---|---|
Induction regimens | ||||
CECV* | Cisplatin | 90 | Day 0 | 90 |
Etoposide | 75 | Days 0–2 | 225 | |
Cyclophosphamide | 1,500 | Days 1 and 2 | 3,000 | |
Vincristine | 1.5 | Days 0 and 7 | 3 | |
VICE* | Carboplatin | 300 | Days 0 and 1 | 600 |
Etoposide | 75 | Days 0–4 | 375 | |
Ifosfamide | 1,500 | Days 0–4 | 7,500 | |
Vincristine | 1.5 | Days 0 and 7 | 3 | |
First HDCT regimen | ||||
CTE | Carboplatin | 500 | Days –8, –7, –6 | 1,500 |
Thiotepa | 300 | Days –5, –4, –3 | 900 | |
Etoposide | 250 | Days –5, –4, –3 | 750 | |
Second HDCT regimen | ||||
CyM | Cyclophosphamide | 1,500 | Days –8, –7, –6, –5 | 6,000 |
Melphalan | 60 | Days –4, –3, –2 | 180 |
CECV = cisplatin + etoposide + cyclophosphamide + vincristine, VICE = vincristine + ifosfamide + carboplatin + etoposide, CTE = carboplatin + thiotepa + etoposide, CyM = cyclophosphamide + melphalan, HDCT = high-dose chemotherapy.
*Dose was determined based on body weight in children under 3 years of age.