Table 3. Characteristics of tandem HDCT/auto-SCT.
| Parameters | CTE regimen (n = 13) | CyM regimen (n = 11) | P value |
|---|---|---|---|
| Hematologic toxicity | |||
| CD34+ cells (× 106/kg) | 20.8 × 106 (1.1–56.7)* | 34.2 (2.2–44.6)* | 0.649 |
| Time (days) to reach an ANC 500/µL† | 8 (8–13) | 9 (8–12) | 0.424 |
| Time (days) to reach a PLT count 20,000/µL‡ | 20 (15–195) | 26 (15–77) | 0.235 |
| Days of BT ≥ 38.0℃ | 5 (3–13) | 0 (0–4) | < 0.001 |
| Positive blood culture | 1 (7.7) | 3 (27.3) | 0.300 |
| Non-hematologic toxicity | |||
| Stomatitis | 7 (63.6) | 0 (0) | 0.004 |
| Vomiting | 3 (23.1) | 2 (18.2) | 0.585 |
| Diarrhea | 10 (76.9) | 5 (45.5) | 0.206 |
| Elevation of liver enzymes | 6 (46.2) | 0 (0) | 0.013 |
| Renal insufficiency§ | 0 (0) | 0 (0) | 1.000 |
| Hypokalemia | 3 (23.1) | 2 (18.2) | 0.585 |
| Hyponatremia | 2 (15.4) | 1 (9.1) | 0.565 |
| Hepatic VOD∥ | 0 (0) | 3 (27.3) | 0.082 |
| Myocarditis | 0 (0) | 0 (0) | 1.000 |
| Seizure | 1 (7.7) | 0 (0) | 0.542 |
| Treatment-related mortality | 0 (0) | 1 (9.1) | 0.471 |
Values are presented as number (%).
CTE = carboplatin + thiotepa + etoposide, CyM = cyclophosphamide + melphalan, HDCT = high-dose chemotherapy, ANC = absolute neutrophil count, PLT = platelet, BT = body temperature, VOD = veno-occlusive disease.
*Median (range); †The first day when ANC exceeded 500/μL for 3 consecutive days; ‡The first day when PLT count exceeded 20,000/μL without transfusion for 7 days; §Elevation of serum creatinine more than threefold of baseline; ∥At least 2 of the following 3 events within 20 days of transplantation: bilirubin level > 2 mg/dL, hepatomegaly or right upper quadrant pain of liver origin, or > 2% weight gain secondary to fluid accumulation.