Table 1. Sequence and schedule of KNOW-CKD Study clinic visits and procedures.
| Parameters | Screen | Baseline | 6 mon | 1 yr | 2 yr | 3 yr | 4 yr | 5 yr | 6 yr | 7 yr | 8 yr | 9 yr | 10 yr |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Informed consent | ● | ||||||||||||
| Demographic information | ● | ||||||||||||
| Medical history | ● | ||||||||||||
| Eligibility confirmation | ● | ||||||||||||
| Recent events | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ||
| Medications | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| Health related questionnaire | ● | ● | |||||||||||
| HRQOL questionnaire | ● | ● | |||||||||||
| BP | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| Anthropometric measures | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| CBC, chemistry | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| IDMS-traceable Cr, eGFR | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| Cystatin C | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| HbA1c (diabetic subjects) | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| Lipid panel, CRP, iron panel | ● | ● | ● | ● | ● | ● | |||||||
| Intact PTH, 25(OH)D, 1,25(OH)D, troponin T | ● | ● | ● | ● | ● | ● | ● | ||||||
| UA with microscopy | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| 24HU – Ca/P/Cr/Urea/Uric acid/protein | ● | ● | ● | ● | ● | ||||||||
| ECG, chest X-ray | ● | ● | ● | ● | ● | ● | |||||||
| Spot urine e', albumin, protein, osmolality, Cr | ● | ● | ● | ● | ● | ● | |||||||
| EchoCG, PWV, ABI, Coronary CT, LS spine lateral X-ray, DEXA BMD | ● | ● | ● | ||||||||||
| Biosamples for DNA | ● | ||||||||||||
| Plasma/urine biosample | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | ● | |
| Fundus exam (DNsubgroup) | ● | ||||||||||||
| Abdomen CT (PKD subgroup) | ● | ● | ● | ● | ● | ● | |||||||
| Family screen (PKD subgroup) | ● |
KNOW-CKD = KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease, HRQOL = health-related quality of life, BP = blood pressure, CBC = complete blood count, Cr = creatinine, eGFR = estimated glomerular filtration rate, HbA1c = hemoglobin A1c, CRP = C-reactive protein, UA = urinalysis, 24HU = 24-hour urine, ECG = electrocardiogram, PTH = parathyroid hormone, 25(OH)D = 25-hydroxyvitamin D, 1,25(OH)D = 1,25-dihydroxyvitamin D, EchoCG = echocardiography, PWV = pulse wave velocity, ABI = ankle-brachial index, CT = computerized tomography, LS = lumbosacral spine, DEXA BMD = dual energy x-ray absorptiometry bone mineral density, DN = diabetic nephropathy, PKD = polycystic kidney disease.