Table 5. Associations between polymorphisms in IRS2 and the risk of T2DM.
| SNPs | Genotypes | T2DM | Additive | Dominant | Recessive | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |||
| Gly1057Asp | n = 305 | n = 467 | ||||||
| AA | 41 (13.4) | 49 (10.5) | 1.422 (1.037–1.949) | 0.029 | 1.461 (1.081–1.973) | 0.014 | 1.339 (0.851–2.106) | 0.207 |
| GA | 153 (50.2) | 208 (44.5) | - | - | - | - | - | - |
| GG | 111 (36.4) | 210 (45.0) | - | - | - | - | - | - |
| −769C/T | n = 293 | n = 455 | ||||||
| CC | 54 (18.4) | 72 (15.8) | 1.216 (0.870–1.700) | 0.252 | 1.243 (0.906–1.705) | 0.177 | 1.182 (0.793–1.761) | 0.412 |
| CT | 143 (48.8) | 217 (47.7) | - | - | - | - | - | - |
| TT | 96 (32.8) | 166 (36.5) | - | - | - | - | - | - |
Genotype distributions are shown as number (%). ORs, 95% CI, and P values were from logistic regression analyses with additive, dominant, and recessive models controlling for age and sex as covariates. In additive models, ORs are expressed per difference in number of rare allele. Genotype were given codes of (0, 1, and 2), (0, 1, and 1), (0, 0, and 1) in additive, dominant and recessive models, respectively.
IRS2 = insulin receptor substrate 2, T2DM = type 2 diabetes mellitus, SNP = single nucleotide polymorphism, OR = odds ratio, CI = confidence interval.