Fig. 3.

Pedigree.

The patient's mother died from a car accident at 45 years of age. His first aunt died from ovarian cancer, and her son from biliary cancer. His second aunt died from colorectal cancer. The 2 daughters of his elder sister were diagnosed with breast cancer at 39 and 36 years of age, and their gene sequencing analyses revealed that both had BRCA2 mutation NM_000059.3:c.3744_3747delTGAG (p.Ser1248Argfs*10).

BRCA2 = breast cancer predisposition gene 2.