Table 3. Functional analysis of genes that significantly distinguish COPD lungs.
| Attribute | Cluster ID | Cluster name | P value | %* |
|---|---|---|---|---|
| Up in COPD | 241 | Growth factor activity | 6.41 × 10−3 | 26.7 |
| Up in COPD | 300 | Signal transductor activity | 3.65 × 10−3 | 9.8 |
| Up in COPD | 402 | Development | 9.70 × 10−3 | 10.5 |
| Up in COPD | 1099 | Cell-surface receptor-linked signal transduction | 4.55 × 10−3 | 15.7 |
| Up in COPD | 1116 | Receptor binding | 4.22 × 10−3 | 17.5 |
| Up in COPD | 1203 | Hormone activity | 4.29 × 10−3 | 42.9 |
| Up in COPD | 1207 | Secretion | 8.22 × 10−3 | 15.6 |
| Down in COPD | 100 | Mitochondrion | 5.49 × 10−3 | 30.1 |
| Down in COPD | 202 | NADH dehydrogenase (ubiquinone) activity | 3.88 × 10−3 | 50 |
| Down in COPD | 231 | Sodium ion transporter activity | 9.97 × 10−3 | 37.9 |
| Down in COPD | 912 | 26S proteasome | 3.95 × 10−3 | 60 |
| Down in COPD | 1117 | NADH dehydrogenase activity | 3.88 × 10−3 | 50 |
| Change in COPD | 1238 | Lipoprotein biosynthesis | 3.48 × 10−3 | 83.3 |
Codelink microarray analysis was performed on independent individual lung tissue samples from GOLD-2 and GOLD-0 smokers.
*
Percentage of the genes in the annotation that are changed in COPD.