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Changes in mean arterial pressure (MAP) and heart rate (HR) over time induced by the intracerebroventricular administration of leptin (n = 5) (7 μg/5 μl), insulin (n = 4) (500 mU/5 μl), saline (n = 5) (5 μl) and the combination of leptin and insulin (n = 4). *P < 0.0001 Leptin alone, insulin alone and both combined compared to saline; #P < 0.0005 leptin and insulin combined compared to insulin alone.
