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. 2017 Jan 9;7:680. doi: 10.3389/fphys.2016.00680

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Copyright © 2017 Januskevicius, Gosens, Sakalauskas, Vaitkiene, Janulaityte, Halayko, Hoppenot and Malakauskas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of eosinophil integrin-blocking on WNT-5a and extracellular matrix protein production in airway smooth muscle (ASM) cells. (A) Influence of eosinophil integrin suppression on WNT-5a gene expression in ASM cells. (B) Influence of eosinophil integrin suppression on fibronectin gene expression in ASM cells. (C) Influence of eosinophil integrin suppression on collagen gene expression in ASM cells. Results are mean ± SEM. Asthma group n = 22; control group n = 17. Negative control, ASM cells that had not been subject to co-culture with eosinophils; EOS control, non-treated eosinophils: 1-h incubation with Arg-Gly-Asp-Ser (RGDS)/Gly-Arg-Ala-Asp-Ser-Pro (GRADSP) in a 0.125 mg/mL final concentration. Statistical significance, p < 0.05.