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. 2017 Jan 9;3:84. doi: 10.3389/fmolb.2016.00084

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Copyright © 2017 Conway de Macario, Robb and Macario.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative analyses of protective capacity of mutant and wild type chaperonins. Protection from heat denaturation of malate dehydrogenase (MDH) by mixed oligomers of Pf-CD1 (red square), Pf-H (green triangle), and Pf-R (purple star) at 37°C (top left panel) and 42°C (top right panel); and protection of MDH at 37°C (bottom left panel) and shrimp alkaline phosphatase (SAP) at 50°C (bottom right panel) by pure hexadecamers. Negative control (no chaperonin added), i.e., MDH, or SAP in bottom right panel, alone: blue diamond. The results shown are mean values (±SD) of triplicate experiments. The loss of enzymatic activity caused by heat was impeded or considerably attenuated by the wild type and Pf-H molecules. In contrast, Pf-R did not have this protective effect, except when purified hexadecamers were used. Source: Min et al., 2014.