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. 2017 Jan 9;7:659. doi: 10.3389/fphys.2016.00659

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Copyright © 2017 Tang, Blair, Walton, Málnási-Csizmadia, Campbell and Yengo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of the muscle sarcomere and the myosin molecule. A simplified diagram of the sarcomere (top panel) demonstrates the location of the myosin thick filaments (A-band) and the actin thin filaments (I-band). A diagram of the myosin molecule (lower panel) demonstrates its overall structure. The myosin heavy chains, light chains (essential light chain, ELC, regulatory light chain, RLC), subfragment 1 (S1) (utilized in the current study), subfragment 2 (S2), heavy meromyosin (HMM), and light meromyosin (LMM) are labeled.