Figure 2.

Diagram of the myosin ATPase cycle. A simplified model of the myosin ATPase cycle shown with two structural states, the pre-power stroke and post-power stroke states. The pre-power stroke state is represented by the smooth muscle myosin structure in the presence of ADP.ALF4 (PDB ID: 1BR4) and the post-power stroke state is represented by the APO myosin V structure (PDB ID: 1OE9). The lever arm is shown in red and the light chain in blue. Actin is indicated by the purple box and the individual steps in the ATPase cycle are described in the text.