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. 2016 Dec 5;97(1):53–69. doi: 10.1038/labinvest.2016.127

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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ASIC1a regulates the PI3K/AKT signaling pathway. (a and b): Western blot analysis showed that the levels of PI3K and phosphorylated AKT were decreased in Bel7402/FU and HepG2/ADM cells treated with ASIC1a shRNA. (c and e, d and f): Histogram shows the semiquantitative analyses of the gels from western blotting. Western blot bands are representative of three independent experiments. The data are means±s.d. of three independent assays (***P<0.001).