Figure 6.

XIAP rescues the effect of miR-137 on apoptosis in SKOV3 cells. (A, B) SKOV3 cells were infected with lentivirus expressing XIAP (LV-XIAP) with MOI of 1 or 2 or with a control (LV-control), with further transfection of the miR-137 mimic or mimic control. The cells were then treated with 10 μg ml⁻¹ cisplatin to trigger apoptosis. DAPI staining was performed as previously described in Figure 3. Representative experiments are shown in A (scale bar, 100 μm) and the statistical results are shown in B. (C) SKOV3 cells were co-transfected with miR-137 mimic or mimic control, and si-XIAP-2 or siRNA control. The apoptotic ratios are shown in a histogram. The average values±s.d. of three separate experiments were plotted, and significant differences from the control value are indicated by *P<0.05.