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. 2016 Nov 24;116(1):58–65. doi: 10.1038/bjc.2016.382

Table 2. Top 10 upregulated and downregulated genes.

Up Function FC (FDR) Down Function FC (FDR)
GSTM2 Detoxification of toxins and products of oxidative stress 3.739 (q=0.0228) CELP −6.476 (q=0.0029)
CYP1B1 Catalysation of metabolites 3.535 (q=0.0002) GRAMD2 −5.865 (q=0.0025)
ANXA1 Inhibits activation of NFKB 3.489 (q=0.0074) CHP2 Regulation of cell proliferation and tumour growth −5.160 (q=0.0086)
ABI3BP Glycosaminoglycan binding 2.561 (q=0.0037) CDHR1 Calcium-dependent cell adhesion molecule −5.123 (q=0.0020)
DES Regulation of sarcomere composition 3.311 (q=0.0005) LRRC31 Regulates apoptosis and NFKB activation −5.104 (q=0.0006)
ABCA6 Regulates ATPase activity 3.240 (q=0.0101) ISM2 Involved in complement pathway −4.753 (q=0.0375)
NAV3 Contributes to growth, differentiation and apoptosis 3.209 (q=0.0351) KLHL32 Involved in protin ubiquitination −4.668 (q=0.0422)
ADAMTS1 Interacts with VEGFA 1.839 (q=0.0438) SLC19A3 Transmembrane receptor −4.495 (q=0.0289)
ADAMTS9 Organ shape during development and angiogenesis 2.255 (q=0.0098) C10orf99 −4.442 (q<0.0001)
HDAC9 Regulates histone deacetylation 3.061 (q=0.0385) NXPE4 −4.372 (q=0.0438)