Table 2. Risk group stratification using risk score generated from miR-204 and miR-139.

	Discovery				Validation
Risk groupa	HRb	95% CI	P-value	Ptrend	HRb	95% CI	P-value	Ptrend
Univariable
Low RS	Ref.				Ref.
Intermediate RS	2.69	0.87–8.34	0.087		1.78	0.64–4.92	0.271
High RS	8.00	2.60–8.34	<0.001	<0.001	4.67	1.80–12.1	0.002	0.001
Multivariable
Low RS	Ref.				Ref.
Intermediate RS	1.15	0.31–4.32	0.834		2.89	0.87–9.57	0.082
High RS	3.45	0.81–14.7	0.094	0.035	6.91	1.94–24.6	0.003	0.003

^aAbbreviations: Low RS= low-risk score consists of high levels of miR-204 and miR-139; Intermediate RS=intermediate-risk score consists of high level of either miR-204 or miR-139; High RS=high-risk score consists of low levels of both miRNAs.

^bMulitivariable model 1: adjusted for age, gender, clinical stage, smoking, hypertension, and obesity (BMI<30 vs BMI>=30).