Table 2. Multivariate analysis of clinicopathological parameters for the prediction of OS, CSS, as well as MFS at 10 years in patients with non-metastatic clear cell renal cell carcinoma (n=587).
|
OS |
CSS |
MFS |
||||
|---|---|---|---|---|---|---|
| Parameter | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
|
Gender | ||||||
| Male | 1 (reference) | 0.510 | 1 (reference) | 0.552 | 1 (reference) | 0.782 |
| Female | 0.849 (0.521–1.382) | 1.252 (0.598–2.623) | 1.086 (0.605–1.950) | |||
|
Age at operation (years) | ||||||
| <65 | 1 (reference) | 0.006 | 1 (reference) | 0.416 | 1 (reference) | 0.951 |
| ⩾65 | 2.078 (1.230–3.510) | 1.373 (0.640–2.945) | 1.019 (0.565–1.838) | |||
|
Tumour grade | ||||||
| G1+G2 | 1 (reference) | 0.126 | 1 (reference) | 0.090 | 1 (reference) | 0.036 |
| G3+G4 | 1.583 (0.878–2.854) | 2.041 (0.895–4.654) | 2.059 (1.049–4.041) | |||
|
Pathologic T-stage | ||||||
| pT1 | 1 (reference) | 0.007 | 1 (reference) | <0.001 | 1 (reference) | <0.001 |
| pT2–4 | 1.993 (1.209–3.286) | 7.805 (2.888–21.095) | 4.273 (2.161–8.451) | |||
|
Presence of tumour necrosis | ||||||
| No | 1 (reference) | 0.729 | 1 (reference) | 0.069 | 1 (reference) | 0.086 |
| Yes | 1.098 (0.646–1.868) | 2.035 (0.946–4.378) | 1.724 (0.925–3.214) | |||
|
dNLR | ||||||
| <2.0 | 1 (reference) | 0.568 | 1 (reference) | 0.037 | 1 (reference) | 0.041 |
| ⩾2.0 | 1.154 (0.706–1.885) | 2.669 (1.062–6.707) | 2.015 (1.031–3.939) | |||
|
Preoperative CRP (mg dl−1) | ||||||
| <10.0 | 1 (reference) | 0.010 | 1 (reference) | 0.039 | 1 (reference) | 0.005 |
| ⩾10.0 | 1.999 (1.180–3.386) | 2.408 (1.045–5.549) | 2.651 (1.344–5.230) | |||
Abbreviations: 95% CI=95% confidence interval; CRP=Creactive protein; CSS=cancer-specific survival; dNLR=derived neutrophil–lymphocyte ratio; HR=hazard ratio; MFS=metastasis-free survival; OS=overall survival.