Table 1. Body and adipose tissue weights, adiposity index and plasma concentrations of leptin in rats fed the STD or the CD and treated with GSPE or the vehicle.
| STD | CD | CD+GSPE | |
|---|---|---|---|
| Initial body wt (g) | 288±9 | 289±14 | 292±17 |
| Final body wt (g) | 443±11a | 531±15 | 511±17 |
| Body wt gain (g) | 155±23a | 242±31 | 219±43 |
| Mesenteric WAT (g) | 6.26±0.6a | 14.00±1.5 | 13.33±0.9 |
| Perirenal WAT (g) | 8.96±0.4a | 20.17±2.0 | 19.51±0.6 |
| Epididymal WAT (g) | 10.02±0.6a | 21.61±2.5 | 18.10±0.8 |
| Adiposity index (%) | 5.80±0.3a | 10.42±0.8 | 9.89±0.2 |
| Leptin (ng ml−1) | 10.09±1.4a | 27.85±2.5 | 25.24±2.4 |
Abbreviations: ANOVA, analysis of variance; CD, cafeteria diet; GSPE, grape-seed proanthocyanidin extract; STD, standard chow diet; WAT, white adipose tissue; wt, weight.
The rats were fed a STD (STD group) or a CD for 10 weeks. After 10 weeks, the rats fed the cafeteria diet were treated orally with GSPE (25 mg per kg of body wt) (CD-GSPE group) or the vehicle (CD group) for 21 days. The adiposity index was computed for each animal as the sum of the different WAT weights, expressed as a percentage of body weight. The values are the means±s.e.m. of seven samples from each group.
a
Denotes significant differences (P<0.05) with respect to both CD and CD+GSPE groups assessed using one-way ANOVA and Tukey's post hoc test.