Fig. 10.

A. A fruiting body of Clitopilus passeckerianus, the pleuromutilin producing basidiomycete (Photograph taken by Tim Colborn). B. The chemical structure of pleuromutilin, the natural product, and the various pleuromutilin derivatives. C. The pleuromutilin gene cluster, recently identified by Bailey et al. (2016), contains the seven genes required to biosynthesise the antibiotic pleuromutilin: A geranylgeranyl disphosphate synthase (GGS), a cyclase, (cyc), three cytochrome P450s, an acetyl transferase (ATF) and a short-chain dehydrogenase/reductase (SDR).