Figure 5.

Increasing neurotransmission from cells specific to the adult circuit enhances diacetyl attraction in a contextually appropriate manner. A, Schematic transforming L3 to adult behavior by knocking down tom-1A in AWC (B), AWB (C), and ASK (D). These manipulations specifically increase synaptic transmission from sensory neurons. B–D, Enhanced attraction in adults is observed only for concentration-appropriate sensory circuits (see also Figs. 2 and 5-1A–C). Chemotaxis improves in L3 worms lacking tom-1A in AWC (B) but not for AWB and ASK tom-1A knockdowns (C, D). Averages and SEM are shown in B–D with numbers on each bar representing the number of assays. Data were compared using unpaired, two-tailed t-tests (*p < 0.05). E, Developmental differences in neurotransmission may underlie plasticity of diacetyl attraction.