Table 3.
Univariate associations between baseline clinical variables and presence of perianal Crohn’s disease
| Clinical Variable | Patients without pCD N=1197 (%) |
Patients with pCD N=524 (%) |
Odds Ratio [95% CI] |
p value |
|---|---|---|---|---|
| Male | 632 (52.8) | 294 (56.1) | 1.14 [0.08–1.58] | 0.23 |
| Non-Jewish ancestry | 705 (58.9) | 344 (66.0) | 1.29 [1.04–1.62] | 0.02 |
| Mean age at diagnosis (Std. dev) | 26 (14.8) | 22.7 (12.7) | 0.98 [0.97–0.99] | <0.001 |
| Median disease duration in yrs | 16.5 | 11.5 | - | <0.001 |
| Family history of IBD | 116 (9.7) | 46 (34.8) | 4.98 [3.30–7.46] | <0.001 |
| Disease location: | ||||
| L1, ileum | 277 (24.3) | 56 (11) | 0.38 [0.28–0.52] | <0.001 |
| L2, colon | 196 (17.2) | 112 (22) | 1.35 [1.04–1.75] | 0.03 |
| L3, ileocolonic | 661 (58.1) | 340 (66.7) | 1.44 [1.16–1.8] | 0.001 |
| L4, upper gastrointestinal | 227 (20.3) | 92 (19) | 92 (0.70–1.20) | 0.55 |
| Colonic disease: | ||||
| Ascending colon | 545 (56.2) | 243 (56.8) | 1.02 [0.81–1.29] | 0.88 |
| Transverse colon | 379 (39.2) | 2.2 (47.5) | 1.4 [1.11–1.77] | 0.01 |
| Descending colon | 385 (39.6) | 227 (51.1) | 1.58 [1.26–1.99] | <0.001 |
| Sigmoid colon | 453 (46.5) | 276 (63.3) | 1.99 [1.58–2.51] | <0.001 |
| Rectum | 360 (36.4) | 325 (71.3) | 4.32 [3.4–5.51] | <0.001 |
| Disease behavior: | ||||
| B1, inflammatory | 571 (48.5) | 207 (39.5) | 0.69 [0.56–0.85] | 0.001 |
| B2, stricturing | 283 (24.0) | 164 (31.3) | 1.44 [1.14–1.81] | 0.002 |
| B3, penetrating | 123 (10.5) | 47 (8.97) | 0.85 [0.59–1.2] | 0.39 |
| B2 and B3, stricturing and penetrating |
200 (17.0) | 105 (20.0) | 1.22 [0.94–1.59] | 0.31 |
| Extra-intestinal manifestations: | ||||
| Ankylosing spondylitis | 68 (6.7) | 39 (8.0) | 1.21 [0.80–1.81] | 0.43 |
| Skin manifestations (EN+PG) | 48 (4.89) | 46 (9.45) | 2.03 [1.33–3.09] | 0.001 |
| Eye symptoms (iritis/uveitis) | 51 (5.28) | 23 (4.73) | 0.89 [0.53–1.47 | 0.75 |
| Primary sclerosing cholangitis | 15 (1.43) | 1 (0.21) | 0.16 [0.01–0.81] | 0.05 |
| Deep vein thrombosis | 25 (2.61) | 17 (3.49) | 1.35 [0.71–2.52] | 0.44 |
| Nephrolithiasis | 67 (6.94) | 46 (9.45) | 1.40 [0.64–2.07] | 0.115 |
| Mean number of abdominal surgeries (Std. dev) |
0.74 (1.04) | 1.14 (1.36) | 1.33 [1.22–1.45] | <0.001 |
IBD, inflammatory bowel disease; pCD, perianal crohns disease; CI, confidence interval; Std. dev, standard deviation; Yrs, years; EN, erythema nodosum; PG, pyoderma gangrenosum