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. 2017 Jan 8;9(1):18–29. doi: 10.4254/wjh.v9.i1.18

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Phosphorylation and dephosphorylation cycles of different phosphoinositides. Monophosphate, diphosphate and triphosphate phosphoinositides are represented, as are the most widely studied kinases (in blue) and phosphatases (in red) that regulate their expression. PtdIns: Phosphatidylinositol; PI3K: Phosphoinositide 3-kinase; SHIP2: SH2-containing inositol polyphosphate 5-phosphatase; PTEN: Phosphatase and tensin homologue deleted on chromosome 10; OCRL: Inositol polyphosphate 5-phosphatase.