Table 4.

Phlebotomy study. Serum metabolome analysis before and after phlebotomy. All concentrations are μM (micromole/L). Data are expressed as means and standard deviations unless otherwise indicated. p-values were assessed by paired Student's t-test and adjusted for multiple comparison. Abbreviations: Met_So – Methioninsulfoxide; PC – phosphatidylcholine, PC_E plasmalogens.

	Baseline	After phlebotomy	Adjusted p-value
Sarcosine	5.98 ± 3.40	5.83 ± 2.90	0.997
Citrulline	35.62 ± 12.62	37.23 ± 10.67	0.559
Glutamate	298.38 ± 180.67	226.41 ± 127.63	0.006
Methionine	22.24 ± 9.84	28.90 ± 9.05	0.006
Met_So	6.30 ± 6.37	2.82 ± 1.74	0.733
PC_36_0	2.50 ± 1.17	1.79 ± 0.90	0.002
PC_38_0	3.36 ± 0.95	2.92 ± 0.91	0.009
PC_38_1	2.50 ± 1.27	1.95 ± 0.72	0.006
PC_38_3	50.02 22.96	49.18 16.91	0.997
PC_38_4	123.18 ± 56.31	120.46 ± 36.78	0.988
PC_40_2	1.34 ± 1.24	0.81 ± 0.64	0.027
PC_40_3	1.24 ± 0.90	0.83 ± 0.52	0.006
PC_40_4	5.43 ± 2.51	5.13 ± 1.88	0.633
PC_42_0	0.61 ± 0.25	0.50 ± 0.19	0.008
PC_42_1	0.43 ± 0.18	0.33 ± 0.12	0.006
PC_42_4	0.55 ± 0.42	0.39 ± 0.26	0.004
PC_42_5	0.70 ± 0.31	0.62 ± 0.23	0.223
PC_E30_0	0.35 ± 0.13	0.33 ± 0.11	0.671
PC_E36_1	11.90 ± 7.85	8.64 ± 4.78	0.001
PC_E38_1	4.81 ± 4.61	3.02 ± 2.89	0.002
PC_E38_2	6.32 ± 5.15	4.39 ± 3.30	0.006
PC_E38_3	12.12 ± 8.58	8.83 ± 5.84	0.001
PC_E40_1	2.10 ± 0.86	1.78 ± 0.59	0.040
PC_E40_2	2.83 ± 1.56	2.13 ± 1.13	0.002
PC_E40_3	5.23 ± 4.53	3.51 ± 2.84	0.002
PC_E40_4	4.37 ± 2.54	3.52 ± 1.85	0.004
PC_E40_5	6.36 ± 3.50	5.12 ± 2.41	0.002
PC_E42_1	0.90 ± 0.65	0.61 ± 0.35	0.004
PC_E44_3	0.28 ± 0.22	0.19 ± 0.15	0.002