Intestinal GLUT2 invalidation reduces jejunal permeability and inflammatory status. (A) Jejunum permeability was measured in control mice (white circles, n = 6) and GLUT2ΔIEC mice (black circles, n = 8) by Ussing Chamber method. FD4 concentration was measured in serosal compartment after a 180-min period. Values are means ± SEM. *P < 0.05; control vs GLUT2ΔIEC mice (Mann–Whitney U test). (B) Relative mRNA levels of pro-inflammatory cytokines IL-1β, IL-6, IL-17, IL-22 and IL-23 in ileal lamina propria lymphocytes of control (white bars, n = 4–5) and GLUT2ΔIEC mice (black bars, n = 3), 4 weeks after tamoxifen administration. Values are means ± SEM. *P < 0.05; Control vs GLUT2ΔIEC mice (Mann–Whitney U test).