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| Model Parameter | Settings |
|---|---|
| Airway Morphometry | Species: Rats |
| FRC = 4.0 ml | |
| URT volume = 0.42 ml | |
| Particle Properties | Density = 0.125 g/cm3 |
| MMAD = 1.17 μm (Single) | |
| GSD = 1.80 μm | |
| Nanoparticle model & inhalability adjustment | |
| Constant exposure | Gravity = 981 cm/s2 |
| Body orientation: On stomach | |
| Aerosol concentration = 1,130 mg/m3 | |
| Breathing Scenario: Nasal | |
| Deposition & Clearance | Rat clearance rate: 0.00105/days |
| Exposure time: 1 h/day, 7 days/week for 4 or 8 weeks |
