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. 2017 Jan 9;7:40153. doi: 10.1038/srep40153

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Copyright © 2017, The Author(s)

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Rats were treated daily with DEHP (0, 250, 500, 750 mg/kg) by gavage for 30 days. Ultrastructural alterations in the thyroid were assessed by TEM analysis. Magnification: X10000. ROS production in cells was evaluated utilizing the oxidant-sensitive probe DCFH-DA. Magnification: X100. (A) DEHP caused ultrastructural changes in rat thyroid. (B) Antioxidant enzymes, GSH-Px and SOD, were depleted; MDA, the product of lipid peroxidation, was accumulated. (C) ROS level in cells was induced by DEHP and was antagonized by NAC. Error bars represent the standard deviation. *P < 0.05, compared with the control. ^#P < 0.05, compared with the DEHP-treated group.