Table 3. Association of AF-specific CpG sites with the most significant cis-gene expression and trans-gene expression.

Type	CpG site	Most significant cis-gene for each AF-related CpG site				Most significant trans-gene for each AF-related CpG site
		Gene	Effect size	SE	P value	Gene+	Effect size	SE	P value
Prevalent AF	cg13639451	HILS1	0.36	0.14	9.1 × 10−3	RPS18	1.85	0.20	4.5 × 10−20
	cg07191189	STRN	0.35	0.12	4.8 × 10−3	LGSN	0.77	0.18	2.3 × 10−5
Incident AF	cg26602477	C1orf159	−0.35	0.16	3.1 × 10−2	PTPN2	−1.37	0.31	1.2 × 10−5
	cg15440392	RPN2	0.21	0.12	7.8 × 10−2	GZMH	−2.18	0.37	7.0 × 10−9
	cg04064828	DPYSL4	0.56	0.23	1.7 × 10−2	ABCA4	−0.98	0.20	7.9 × 10−7
	cg27529934	PLEKHA6	0.26	0.09	5.6 × 10−3	ADAMTS2	0.40	0.09	1.3 × 10−5
	cg06725760	ZMYND11	−0.22	0.21	2.8 × 10−1	GZMH	−3.01	0.72	3.2 × 10−5

^*SE: Standard error.

⁺All the most significant genes are located in different chromosomes from the corresponding CpG sites.

^*SE: Standard error.