Table 1. Parameters and initial conditions taken from ref. 48 unless otherwise indicated.

Parameter	Meaning	Value
Viral kinetic parameters
β	Infection rate	3.2 × 10−5 d−1 ⋅ [TCID50/mL]−1
p	Production rate	4.6 × 10−2TCID50⋅d−1⋅mL−1
c	Clearance rate	5.2 d−1
τE	Eclipse phase, mean duration	6 h
σE	Eclipse phase, standard deviation	1 h45
τI	Infectious lifespan, mean duration	12 h45
σI	Infectious lifespan, standard deviation	1 h45
Initial conditions
T0	Initial number of target cells	4 × 108cells
E0	Initial number of eclipse cells	0 cells
I0	Initial number of infectious cells	0 cells
V0	Initial amount of virus	7.5 × 10−2TCID50
Pharmacokinetic/pharmacodynamic parameters
ka	Drug absorption rate	0.46 h−1 54
ke	Drug elimination rate	0.11 h−1 54
EC50	50% effective concentration	7.3 mg [see text]
εmax	Maximum inhibitory effect	0.98 [see text]