Figure 1. Aligned Fibrin hydrogel (AFG) scaffold and canine hemisected spinal cord injury model.

Macro-photo (A) and micrograph (B,C) taken by scanning electron microscope show network architecture of AFG, the nanofiber. Longitudinal section of AFG scaffold demonstrating the aligned nanoscale fibrous structure (B,C). hMSCs cultured on the AFG scaffold for 3 days (red was f-actin and blue was nucleus) (D). Schematic diagram of the hemisection model (E). AFG scaffold implantation procedure included exposing of the spinal cord (F), hemisection (G) and filling of the AFG scaffold into the defect (H).