Table 3. Stratified analysis of pri-let-7e rs8111742, pri-miR-365b rs121224, pri-miR-4795 rs1002765 and risk of atrophic gastritis and gastric cancer.
| Variables | Genotype | Atrophic gastritis group vs. control group | P | OR(95%CI) | Cancer group vs. control group | P | OR(95%CI) |
|---|---|---|---|---|---|---|---|
| pri-let7e rs8111742 | |||||||
| H. pyloria | n = 862 vs 862 | n = 724 vs 729 | |||||
| Negative | GG | 193/329 | 1.00 | 196/278 | 1.00 | ||
| GA | 139/245 | 0.814 | 0.97(0.74–1.27) | 138/206 | 0.700 | 0.95(0.71–1.26) | |
| AA | 25/47 | 0.685 | 0.90(0.54–1.51) | 21/44 | 0.181 | 0.69(0.40–1.19) | |
| GA + AA VS. GG | 0.746 | 0.96(0.74–1.24) | 0.445 | 0.90(0.69–1.18) | |||
| AA VS. GA + GG | 0.737 | 0.92(0.55–1.52) | 0.185 | 0.69(0.41–1.19) | |||
| Positive | GG | 265/130 | 1.00 | 179/111 | 1.00 | ||
| GA | 204/96 | 0.658 | 1.08(0.78–1.49) | 153/79 | 0.316 | 1.21(0.84–1.74) | |
| AA | 36/15 | 0.641 | 1.16(0.62–2.21) | 37/11 | 0.044 | 2.09(1.02–4.26) | |
| GA + AA VS. GG | 0.598 | 1.09(0.80–1.48) | 0.118 | 1.32(0.93–1.87) | |||
| AA VS. GA + GG | 0.707 | 1.13(0.60–2.11) | 0.064 | 1.94(0.96–3.89) | |||
| Smoking statusb | n = 548 vs 586 | n = 333 vs 500 | |||||
| Smokers | GG | 86/106 | 1.00 | 72/104 | 1.00 | ||
| GA | 70/79 | 0.566 | 1.14(0.73–1.80) | 65/78 | 0.416 | 1.22(0.76–1.96) | |
| AA | 17/17 | 0.452 | 1.35(0.62–2.92) | 11/17 | 0.754 | 0.87(0.35–2.14) | |
| GA + AA VS. GG | 0.442 | 1.19(0.77–1.83) | 0.519 | 1.16(0.74–1.84) | |||
| AA VS. GA + GG | 0.523 | 1.28(0.60–2.70) | 0.590 | 0.78(0.32–1.92) | |||
| Non-smokers | GG | 207/199 | 1.00 | 98/159 | 1.00 | ||
| GA | 143/160 | 0.213 | 0.81(0.59–1.13) | 74/122 | 0.500 | 0.87(0.58–1.31) | |
| AA | 25/25 | 0.859 | 1.06(0.56–2.03) | 13/20 | 0.974 | 1.01(0.46–2.22) | |
| GA + AA VS. GG | 0.286 | 0.84(0.62–1.15) | 0.535 | 0.88(0.60–1.31) | |||
| AA VS. GA + GG | 0.695 | 1.13(0.61–2.11) | 0.838 | 1.08(0.50–2.33) | |||
| Drinking statusb | n = 547 vs 585 | n = 296 vs 499 | |||||
| Drinkers | GG | 60/74 | 1.00 | 48/73 | 1.00 | ||
| GA | 49/63 | 0.884 | 0.96(0.57–1.63) | 51/63 | 0.286 | 1.34(0.78–2.31) | |
| AA | 15/10 | 0.161 | 1.87(0.78–4.51) | 8/10 | 0.780 | 1.16(0.41–3.30) | |
| GA + AA VS. GG | 0.736 | 1.09(0.66–1.79) | 0.289 | 1.33(0.79–2.25) | |||
| AA VS. GA + GG | 0.136 | 1.94(0.81–4.61) | 0.965 | 0.98(0.35–2.71) | |||
| Non-drinkers | GG | 234/228 | 1.00 | 100/187 | 1.00 | ||
| GA | 163/177 | 0.417 | 0.88(0.65–1.20) | 75/138 | 0.388 | 0.84(0.56–1.25) | |
| AA | 26/33 | 0.586 | 0.84(0.46–1.56) | 14/28 | 0.851 | 0.93(0.45–1.93) | |
| GA + AA VS. GG | 0.371 | 0.87(0.65–1.17) | 0.387 | 0.85(0.58–1.24) | |||
| AA VS. GA + GG | 0.675 | 0.88(0.49–1.58) | 0.963 | 1.02(0.50–2.08) | |||
| pri-miR-365b rs121224 | |||||||
| H. pyloria | n = 862 vs 862 | n = 724 vs 729 | |||||
| Negative | CC | 79/118 | 1.00 | 68/99 | 1.00 | ||
| CG | 160/304 | 0.402 | 0.88(0.65–1.19) | 182/258 | 0.403 | 1.14(0.84–1.56) | |
| GG | 118/199 | 0.492 | 1.14(0.79–1.64) | 105/171 | 0.612 | 1.11(0.75–1.64) | |
| CG + GG VS. CC | 0.713 | 0.95(0.72–1.25) | 0.411 | 1.13(0.84–1.52) | |||
| GG VS. CG + CC | 0.235 | 1.22(0.88–1.67) | 0.901 | 1.02(0.73–1.44) | |||
| Positive | CC | 98/46 | 1.00 | 59/39 | 1.00 | ||
| CG | 253/124 | 0.85 | 0.97(0.68–1.38) | 194/104 | 0.806 | 0.95(0.64–1.42) | |
| GG | 154/71 | 0.966 | 1.01(0.64–1.59) | 116/58 | 0.262 | 0.74(0.44–1.25) | |
| CG + GG VS. CC | 0.886 | 0.98(0.70–1.37) | 0.565 | 0.90(0.61–1.31) | |||
| GG VS. CG + CC | 0.915 | 1.02(0.69–1.51) | 0.263 | 0.77(0.49–1.21) | |||
| Smoking statusb | n = 548 vs 586 | n = 333 vs 500 | |||||
| Smokers | CC | 32/31 | 1.00 | 23/30 | 1.00 | ||
| CG | 87/97 | 0.413 | 1.23(0.75–1.99) | 81/95 | 0.273 | 1.34(0.80–2.24) | |
| GG | 54/74 | 0.442 | 1.30(0.67–2.53) | 44/74 | 0.688 | 1.16(0.57–2.36) | |
| CG + GG VS. CC | 0.371 | 1.23(0.78–1.95) | 0.303 | 1.29(0.79–2.12) | |||
| GG VS. CG + CC | 0.576 | 1.18(0.66–2.10) | 0.954 | 0.98(0.52–1.85) | |||
| Non-smokers | CC | 81/75 | 1.00 | 32/63 | 1.00 | ||
| CG | 172/194 | 0.29 | 0.82(0.58–1.18) | 100/150 | 0.402 | 1.21(0.77–1.90) | |
| GG | 122/115 | 0.849 | 0.96(0.62–1.48) | 53/88 | 0.496 | 0.82(0.45–1.47) | |
| CG + GG VS. CC | 0.387 | 0.86(0.62–1.21) | 0.699 | 1.09(0.71–1.67) | |||
| GG VS. CG + CC | 0.745 | 1.07(0.72–1.57) | 0.210 | 0.73(0.44–1.20) | |||
| Drinking statusb | n = 547 vs 585 | n = 296 vs 499 | |||||
| Drinkers | CC | 25/21 | 1.00 | 19/20 | 1.00 | ||
| CG | 64/81 | 0.583 | 1.18(0.66–2.09) | 57/81 | 0.652 | 1.15(0.63–2.09) | |
| GG | 35/45 | 0.19 | 1.69(0.77–3.70) | 31/45 | 0.305 | 1.54(0.68–3.51) | |
| CG + GG VS. CC | 0.369 | 1.29(0.74–2.23) | 0.497 | 1.22(0.69–2.17) | |||
| GG VS. CG + CC | 0.29 | 1.43(0.74–2.76) | 0.365 | 1.39(0.68–2.83) | |||
| Non-drinkers | CC | 88/84 | 1.00 | 30/72 | 1.00 | ||
| CG | 195/210 | 0.393 | 0.86(0.62–1.21) | 104/164 | 0.267 | 1.28(0.83–1.97) | |
| GG | 140/144 | 0.872 | 0.97(0.64–1.46) | 55/117 | 0.308 | 0.74(0.41–1.32) | |
| CG + GG VS. CC | 0.487 | 0.90(0.65–1.22) | 0.617 | 1.11(0.74–1.68) | |||
| GG VS. CG + CC | 0.839 | 1.04(0.72–1.50) | 0.087 | 0.645(0.39–1.07) | |||
| pri-miR4795 rs1002765 | |||||||
| H. pyloria | n = 862 vs 862 | n = 724 vs 729 | |||||
| Negative | GG | 112/232 | 1.00 | 130/197 | 1.00 | ||
| GA | 183/302 | 0.108 | 1.27(0.95–1.70) | 167/259 | 0.982 | 1.00(0.74–1.34) | |
| AA | 62/87 | 0.055 | 1.47(0.99–2.19) | 58/72 | 0.387 | 1.20(0.79–1.82) | |
| GA + AA VS. GG | 0.051 | 1.32(1.00–1.74) | 0.770 | 1.04(0.79–1.38) | |||
| AA VS. GA + GG | 0.158 | 1.29(0.91–1.84) | 0.307 | 1.22(0.84–1.77) | |||
| Positive | GG | 192/75 | 1.00 | 142/65 | 1.00 | ||
| GA | 233/118 | 0.143 | 0.77(0.54–1.09) | 182/98 | 0.429 | 0.86(0.58–1.26) | |
| AA | 80/48 | 0.129 | 0.70(0.45–1.11) | 45/38 | 0.050 | 0.58(0.34–1.00) | |
| GA + AA VS. GG | 0.085 | 0.75(0.54–1.04) | 0.186 | 0.78(0.54–1.13) | |||
| AA VS. GA + GG | 0.293 | 0.81(0.54–1.21) | 0.055 | 0.63(0.39–1.01) | |||
| Smoking statusb | n = 548 vs 586 | n = 333 vs 500 | |||||
| Smokers | GG | 53/73 | 1.00 | 60/73 | 1.00 | ||
| GA | 86/105 | 0.517 | 1.18(0.72–1.93) | 71/102 | 0.514 | 0.85(0.52–1.39) | |
| AA | 34/24 | 0.073 | 1.93(0.94–3.96) | 17/24 | 0.462 | 0.74(0.33–1.65) | |
| GA + AA VS. GG | 0.279 | 1.29(0.81–2.06) | 0.470 | 0.84(0.52–1.35) | |||
| AA VS. GA + GG | 0.087 | 1.70(0.93–3.14) | 0.655 | 0.85(0.41–1.75) | |||
| Non-smokers | GG | 139/130 | 1.00 | 62/98 | 1.00 | ||
| GA | 182/190 | 0.705 | 0.94(0.66–1.32) | 99/156 | 0.909 | 0.98(0.63–1.50) | |
| AA | 54/64 | 0.247 | 0.76(0.47–1.22) | 24/47 | 0.519 | 0.82(0.45–1.50) | |
| GA + AA VS. GG | 0.463 | 0.89(0.64–1.23) | 0.750 | 0.94(0.62–1.41) | |||
| AA VS. GA + GG | 0.271 | 0.78(0.51–1.21) | 0.526 | 0.84(0.48–1.46) | |||
| Drinking statusb | n = 547 vs 585 | n = 296 vs 499 | |||||
| Drinkers | GG | 35/47 | 1.00 | 40/47 | 1.00 | ||
| GA | 65/76 | 0.674 | 1.13(0.64–2.01) | 51/75 | 0.328 | 0.75(0.42–1.34) | |
| AA | 24/24 | 0.334 | 1.46(0.68–3.17) | 16/24 | 0.607 | 0.81(0.35–1.84) | |
| GA + AA VS. GG | 0.513 | 1.20(0.70–2.07) | 0.347 | 0.77(0.44–1.33) | |||
| AA VS. GA + GG | 0.365 | 1.36(0.70–2.64) | 0.935 | 0.97(0.47–2.02) | |||
| Non-drinkers | GG | 156/156 | 1.00 | 61/124 | 1.00 | ||
| GA | 203/218 | 0.979 | 1.00(0.73–1.39) | 104/182 | 0.650 | 1.10(0.72–1.68) | |
| AA | 64/64 | 0.657 | 0.90(0.57–1.43) | 24/47 | 0.941 | 0.98(0.53–1.80) | |
| GA + AA VS. GG | 0.893 | 0.98(0.72–1.33) | 0.722 | 1.08(0.72–1.61) | |||
| AA VS. GA + GG | 0.639 | 0.91(0.60–1.37) | 0.741 | 0.91(0.52–1.60) | |||
Note: aP values were adjusted by age and sex; bP values were adjusted by age, sex and H. pylori infection status.