Table 6. Correlation between pri-let-7e rs8111742, pri-miR-365b rs121224, pri-miR-4795 rs1002765 polymorphism and clinical pathological parameters.
| Clinical pathological parameters | Case number | Genotype |
Dominant model P | Recessive model P | ||
|---|---|---|---|---|---|---|
| wild type | hybrid type | mutation type | ||||
| pri-let7e rs8111742 | 357 | |||||
| Age | 0.113 | 0.802 | ||||
| ≤60 | 168 | 73(43.5) | 82(48.8) | 13(7.7) | ||
| >60 | 189 | 98(51.9) | 75(39.7) | 16(8.5) | ||
| Gender | 0.228 | 0.902 | ||||
| Male | 255 | 117(45.9) | 117(45.9) | 21(8.2) | ||
| Female | 102 | 54(52.9) | 40(39.2) | 8(7.8) | ||
| Borrmann type | 0.850 | 0.564 | ||||
| Borrmann I–II | 83 | 39(47.0) | 36(43.4) | 8(9.6) | ||
| Borrmann III–IV | 274 | 132(48.2) | 121(44.2) | 21(7.7) | ||
| Lauren type | 0.064 | 0.138 | ||||
| Intestinal type | 120 | 66(55.0) | 48(40.0) | 6(5.0) | ||
| Diffuse type | 231 | 103(44.6) | 106(45.9) | 22(9.5) | ||
| Non classified carcinoma | 6 | 2(33.3) | 3(50.0) | 1(16.7) | ||
| TNM staging | 0.280 | 0.131 | ||||
| I–II | 171 | 87(50.9) | 74(43.3) | 10(5.8) | ||
| III–IV | 186 | 84(45.2) | 83(44.6) | 19(10.2) | ||
| Depth of invasion | 0.989 | 0.652 | ||||
| T1 + T2 | 98 | 47(48.0) | 42(42.9) | 9(9.2) | ||
| T3 + T4 | 259 | 124(47.9) | 115(44.4) | 20(7.7) | ||
| Lymph node metastasis | 0.325 | 0.121 | ||||
| Positive | 216 | 98(45.4) | 95(44.0) | 23(10.6) | ||
| Negative | 141 | 73(51.8) | 62(44.0) | 6(4.3) | ||
| pri-miR-365b rs121224 | 347 | |||||
| Age | 0.647 | 0.507 | ||||
| ≤60 | 163 | 47(28.8) | 85(52.1) | 31(19.0) | ||
| >60 | 184 | 49(26.6) | 105(57.1) | 30(16.3) | ||
| Gender | 0.193 | 0.809 | ||||
| Male | 249 | 64(25.7) | 142(57.0) | 43(17.3) | ||
| Female | 98 | 32(32.7) | 48(49.0) | 18(18.4) | ||
| Borrmann type | 0.393 | 0.235 | ||||
| Borrmann I–II | 83 | 26(31.3) | 46(55.4) | 11(13.3) | ||
| Borrmann III–IV | 264 | 70(26.5) | 144(54.5) | 50(18.9) | ||
| Lauren type | 0.329 | 0.014b | ||||
| Intestinal type | 118 | 36(30.5) | 53(44.9) | 29(24.6) | ||
| Diffuse type | 223 | 57(25.6) | 135(60.5) | 31(13.9) | ||
| Non classified carcinoma | 6 | |||||
| TNM staging | 0.961 | 0.031c | ||||
| I–II | 167 | 46(27.5) | 84(50.3) | 37(22.2) | ||
| III–IV | 180 | 50(27.8) | 106(58.9) | 24(13.3) | ||
| Depth of invasion | 0.976 | 0.809 | ||||
| T1 + T2 | 98 | 27(27.6) | 53(54.1) | 18(18.4) | ||
| T3 + T4 | 249 | 69(27.7) | 137(55.0) | 43(17.3) | ||
| Lymph node metastasis | 0.237 | 0.624 | ||||
| Positive | 210 | 56(26.7) | 120(57.1) | 34(16.2) | ||
| Negative | 137 | 40(29.2) | 70(51.1) | 27(19.7) | ||
| pri-mir4795 rs1002765 | 357 | |||||
| Age | 0.170 | 0.240 | ||||
| ≤60 | 168 | 65(38.7) | 82(48.8) | 21(12.5) | ||
| >60 | 189 | 60(31.7) | 97(51.3) | 32(16.9) | ||
| Gender | 0.160 | 0.541 | ||||
| Male | 255 | 95(37.3) | 124(48.6) | 36(14.1) | ||
| Female | 102 | 30(29.4) | 55(53.9) | 17(16.7) | ||
| Borrmann type | 0.064 | 0.345 | ||||
| Borrmann I–II | 83 | 22(26.5) | 46(55.4) | 15(18.1) | ||
| Borrmann III–IV | 274 | 103(37.6) | 133(48.5) | 38(13.9) | ||
| Lauren type | 0.823 | 0.782 | ||||
| Intestinal type | 120 | 43(35.8) | 58(48.3) | 19(15.8) | ||
| Diffuse type | 231 | 80(34.6) | 117(50.6) | 34(14.7) | ||
| Non classified carcinoma | 6 | 2(33.3) | 4(66.6) | 0(0.0) | ||
| TNM staging | 0.846 | 0.908 | ||||
| I–II | 171 | 59(34.5) | 87(50.9) | 25(14.6) | ||
| III–IV | 186 | 66(35.5) | 92(49.5) | 28(15.1) | ||
| Depth of invasion | 0.565 | 0.880 | ||||
| T1 + T2 | 98 | 32(32.7) | 51(52.0) | 15(15.3) | ||
| T3 + T4 | 259 | 93(35.9) | 128(49.4) | 38(14.7) | ||
| Lymph node metastasis | 0.753 | 0.916 | ||||
| Positive | 216 | 75(34.7) | 109(50.5) | 32(14.8) | ||
| Negative | 141 | 50(35.5) | 70(49.6) | 21(14.9) | ||
Note: a, using chi square test; b, a multivariate regression analysis was used to correct for age and sex factors P = 0.014, OR = 1.42, 95%CI = 0.87–2.47; c, a multivariate regression analysis was used to correct for age and sex factors P = 0.031, OR = 1.37, 95%CI = 1.03–1.82.