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. 2017 Jan 9;7:40252. doi: 10.1038/srep40252

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Degree maps k_ALS < HC and k_ALS > HC are superimposed on top of MNI slices in order to map clusters of decreased and increased connectivity in ALS, respectively. The degree k_ALS < HC (k_ALS > HC) of a voxel/node v is the number of pairs (v, w) in G_t, exhibiting significantly decreased (increased) functional connectivity (FDR < 0.05), where w can be any other voxel than v.