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. 2017 Jan 9;7:40098. doi: 10.1038/srep40098

Table 3. Cell cytotoxicity and calculated target selectivity parameter (TSP) values of anti-EGFR/HER2 bsAb variants.

Cell	Parental NCI-H358	NCI-H358.HER2.ko
Antibody	IC₅₀ (nM)	IC₅₀ (nM)	Mean TSP^a
EGFR/HER2 DuetMab	1.1	10.7	0.09 ± 0.006
VκF94A/HER2 DuetMab	1.8	20.9	0.07 ± 0.009
VκS93A + V_HP97A/HER2 DuetMab	4.1	296	0.01 ± 0.001
VκF94A + V_HP97A/HER2 DuetMab	18.6	3251	0.006 ± 0.0002
VκS93A + V_HP97A/HER2 IgG-scFv	4.0	17.0	0.21 ± 0.012
VκF94A + V_HP97A/HER2 IgG-scFv	17.8	148.8	0.13 ± 0.006

^aTSP: Mean TSP values based on data from three independent experiments ± SEM.