Table 2. Functional annotation analysis of liver genes using the DAVID tool.

GO terms in the Biological Process ontology	n	adj p-value	FE
GO:0042493~response to drug	23	1.9E-08	6.0
GO:0055114~oxidation-reduction process	24	2.1E-07	4.9
GO:0006457~protein folding	11	3.0E-06	12.9
GO:0071353~cellular response to interleukin-4	7	7.8E-06	34.2
GO:0006412~translation	16	1.3E-05	5.9
GO:0006749~glutathione metabolic process	8	1.1E-05	21.1
GO:0001889~liver development	10	9.9E-05	9.6
GO:0045471~response to ethanol	10	6.8E-04	7.5
GO:0006641~triglyceride metabolic process	6	6.6E-04	21.4
GO:0006979~response to oxidative stress	9	7.6E-04	8.5
KEGG pathway annotation	n	adj p-value	FE
rno01100:Metabolic pathways	55	1.4E-12	2.9
rno01130:Biosynthesis of antibiotics	19	1.7E-07	5.8
rno04141:Protein processing in endoplasmic reticulum	16	7.1E-07	6.5
rno01230:Biosynthesis of amino acids	12	9.4E-07	9.8
rno01200:Carbon metabolism	13	4.2E-06	7.3
rno03010:Ribosome	14	2.6E-05	5.5
rno00071:Fatty acid degradation	8	9.1E-05	11.5
rno00280:Valine, leucine and isoleucine degradation	8	2.3E-04	9.8
rno04146:Peroxisome	9	4.7E-04	7.1
rno00410:beta-Alanine metabolism	6	1.7E-03	11.9

The rat genome was used as a background list to calculate the p-values of each term. A total of 131 genes were recognised. The p-values were calculated according to a modified Fisher’s exact test (EASE score) and adjusted according to the Benjamini-Hochberg method. The fold enrichment (FE) of the statistically most overrepresented (enriched) GO biological process and KEGG pathway terms are presented.