Table 3. List of liver metabolites having their levels significantly altered by the Roundup treatment.
| PUBCHEM ID | BIOCHEMICAL | FC | p-value | BH adj p-value |
|---|---|---|---|---|
| 557 | N-methyl proline | 2.27 | 8.2E-05 | 4.1E-02 |
| 76406 | N-acetyl-beta-alanine | 1.62 | 1.5E-04 | 4.1E-02 |
| 439924 | nicotinamide riboside | −2.79 | 2.1E-04 | 4.1E-02 |
| 1102 | spermidine | 1.64 | 4.9E-04 | 7.3E-02 |
| 439281 | N-acetylmannosamine | 2.13 | 1.1E-03 | 1.3E-01 |
| 11025495 | cholesterol | 1.16 | 1.5E-03 | 1.5E-01 |
| 5789 | thymidine | 1.96 | 2.9E-03 | 2.5E-01 |
| 13711 | 2′-deoxycytidine | 1.39 | 3.9E-03 | 2.6E-01 |
| 9794176 | gulonic acid | 1.07 | 3.9E-03 | 2.6E-01 |
| 190 | adenine | 1.66 | 5.2E-03 | 2.8E-01 |
| 439197 | N-acetylneuraminate | 1.19 | 5.2E-03 | 2.8E-01 |
| 440129 | imidazole lactate | 1.44 | 5.7E-03 | 2.8E-01 |
| 0 | chiro-inositol | 1.53 | 6.8E-03 | 2.9E-01 |
| 750 | glycine | 1.21 | 6.8E-03 | 2.9E-01 |
| NA | 2,8-quinolinediol | 2.52 | 7.8E-03 | 3.1E-01 |
| 69362 | beta-hydroxyisovalerate | 1.61 | 8.9E-03 | 3.4E-01 |
| 187790 | 2′-deoxyguanosine | 1.58 | 1.0E-02 | 3.4E-01 |
| 65058 | 2′-deoxyinosine | 1.61 | 1.0E-02 | 3.4E-01 |
| 3083879 | catechol sulfate | 2.08 | 1.1E-02 | 3.6E-01 |
| 5960 | aspartate | 1.50 | 1.5E-02 | 3.7E-01 |
| 123831 | dimethylarginine (SDMA + ADMA) | 1.16 | 1.5E-02 | 3.7E-01 |
| 151023 | gamma-glutamylleucine | 1.57 | 1.5E-02 | 3.7E-01 |
| 611 | glutamate | 1.31 | 1.5E-02 | 3.7E-01 |
| 151152 | threonate | 1.29 | 1.5E-02 | 3.7E-01 |
| 439176 | 5-methylthioadenosine (MTA) | 1.78 | 1.9E-02 | 4.0E-01 |
| 68662 | glutamate, gamma-methyl ester | 1.35 | 1.9E-02 | 4.0E-01 |
| 5810 | trans-4-hydroxyproline | 1.85 | 1.9E-02 | 4.0E-01 |
| 64960 | 1,5-anhydroglucitol (1,5-AG) | 1.38 | 2.3E-02 | 4.0E-01 |
| 9378 | 3-(4-hydroxyphenyl)lactate | −1.51 | 2.3E-02 | 4.0E-01 |
| 6267 | asparagine | 1.12 | 2.3E-02 | 4.0E-01 |
| 107812 | hypotaurine | −1.74 | 2.3E-02 | 4.0E-01 |
| 0 | methyl glucopyranoside (alpha + beta) | 1.38 | 2.3E-02 | 4.0E-01 |
| 7018721 | ophthalmate | 3.47 | 2.3E-02 | 4.0E-01 |
| 11673055 | pro-hydroxy-pro | 2.01 | 2.3E-02 | 4.0E-01 |
| 1135 | thymine | 1.49 | 2.3E-02 | 4.0E-01 |
| 440364 | N-acetyl-glucosamine 1-phosphate | −1.90 | 2.8E-02 | 4.0E-01 |
| 469 | 2-aminoadipate | 1.39 | 2.9E-02 | 4.0E-01 |
| 128145 | 3-methylglutarylcarnitine (2) | 1.85 | 2.9E-02 | 4.0E-01 |
| 440055 | 5-methyl-2′-deoxycytidine | 1.21 | 2.9E-02 | 4.0E-01 |
| 6441454 | docosapentaenoate (n6 DPA; 22:5n6) | 1.72 | 2.9E-02 | 4.0E-01 |
| 65254;14284565 | gamma-glutamyllysine | 1.46 | 2.9E-02 | 4.0E-01 |
| 53481617 | hydroxybutyrylcarnitine | 1.57 | 2.9E-02 | 4.0E-01 |
| 92751 | orotidine | 1.38 | 2.9E-02 | 4.0E-01 |
| 129397 | acisoga | 1.95 | 3.5E-02 | 4.5E-01 |
| 3013625 | glycylproline | 1.60 | 3.5E-02 | 4.5E-01 |
| 14180 | nicotinamide ribonucleotide (NMN) | −2.35 | 3.5E-02 | 4.5E-01 |
| 6602431 | xylonate | 1.62 | 3.5E-02 | 4.5E-01 |
| 1045 | putrescine | 1.77 | 3.6E-02 | 4.5E-01 |
| 65065 | N-acetylaspartate (NAA) | 2.08 | 4.3E-02 | 4.8E-01 |
| 70912 | N-acetylleucine | 1.61 | 4.3E-02 | 4.8E-01 |
| 5489007 | norophthalmate | 2.42 | 4.3E-02 | 4.8E-01 |
| 10253 | 2-hydroxyhippurate (salicylurate) | 4.30 | 4.3E-02 | 4.8E-01 |
| 64956 | 3-aminoisobutyrate | 1.38 | 4.3E-02 | 4.8E-01 |
| 444485 | 3′-dephosphocoenzyme A | −1.54 | 4.3E-02 | 4.8E-01 |
| 7019993 | asparagylvaline | 2.34 | 4.3E-02 | 4.8E-01 |
| 445408 | 5-methyluridine (ribothymidine) | 1.61 | 5.2E-02 | 4.9E-01 |
| 2266 | azelate (nonanedioate) | 1.23 | 5.2E-02 | 4.9E-01 |
| 14253342 | gamma-glutamylisoleucine | 1.49 | 5.2E-02 | 4.9E-01 |
| 6426853 | hexanoylcarnitine | 1.50 | 5.2E-02 | 4.9E-01 |
| 2802421 | N-acetylisoleucine | 1.82 | 5.2E-02 | 4.9E-01 |
| 74839 | N-acetylphenylalanine | 1.82 | 5.2E-02 | 4.9E-01 |
| 152204 | N-acetylthreonine | 1.32 | 5.2E-02 | 4.9E-01 |
| 34755 | S-adenosylmethionine (SAM) | 1.84 | 5.2E-02 | 4.9E-01 |
| 1174 | uracil | 1.36 | 5.2E-02 | 4.9E-01 |
Levels of each metabolite from the metabolomics of livers from female rats receiving the herbicide Roundup in their drinking water were subjected to a statistical analysis by comparison to controls using a Mann–Whitney U test. A selection of metabolites showing a statistically significant change, as well as their fold changes and p-values is shown.