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Cumulative dose-response curves and sensitivity to ACh in the absence (control, ●) and presence of the COX inhibitor, indomethacin (1 μM, □) in the mesenteric arteries of (A) CB + Placebo, (B) STZ + Placebo and (C) STZ + RLX treated mice. n = 9–13 per group. Data (mean ± SEM) are expressed as % U46619 contraction. #pEC50 significantly (P < 0.0001) different to control.
