Table 1. Systemic analysis of CB+Placebo, STZ+Placebo and STZ+RLX treated mice.
| CB+Placebo | STZ+Placebo | STZ+RLX | |
|---|---|---|---|
| n | 10 | 12 | 12 |
| HbA1c (%) | 4.6 ± 0.1ψ | 11.7 ± 0.6 | 12.3 ± 0.6 |
| Plasma osmolality (mmol/kg) | 306.4 ± 2.3ψ | 336.6 ± 3.7 | 332.3 ± 2.4 |
| Body weight (g) | 28.6 ± 0.9ψ | 23.4 ± 0.2 | 22.9 ± 0.2 |
| Tibia length (mm) | 16.2 ± 0.4 | 16.0 ± 0.2 | 15.9 ± 0.2 |
| Heart weight/TL (mg/mm) | 8.1 ± 0.4# | 6.4 ± 0.4 | 6.1 ± 0.3 |
| Left ventricle/TL (mg/mm) | 5.8 ± 0.3ψ | 4.5 ± 0.2 | 4.4 ± 0.2 |
| Right ventricle/TL (mg/mm) | 1.6 ± 0.1# | 1.2 ± 0.1 | 1.1 ± 0.1 |
| Atria/TL (mg/mm) | 0.6 ± 0.0 | 0.5 ± 0.1 | 0.4 ± 0.0 |
Values are expressed as mean ± SEM; n represents number of mice in the group. CB, citrate buffer; STZ, streptozotocin; RLX, serelaxin; HbA1c, glycated haemoglobin; TL, tibia length. ψP < 0.0001, #P < 0.001, *P < 0.05 (vs STZ+Placebo).