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. 2017 Jan 9;7:40485. doi: 10.1038/srep40485

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(A) Genotype ratios of heterozygous crosses at different embryonic stages and weaning. 9–13 litters were analysed at each stage. n.d.* resorbed embryos; undetermined genotypes. (B) Examples of E10.5, E14.5 and E18.5 IRSp53 heterozygous and KO embryos. Arrowheads point to the pericardium; arrows denote blood vessels. (C,D) Alcian blue/Alizarin red staining of E14.5 and E18.5 forelimbs (C) and E18.5 skulls (D). Panels I, II: ventral views of the skulls. Panels III, IV: higher magnification of the cranial base. Arrowheads: clefts in the basisphenoid (bs) and basioccipital (bo).