Table 1.
Metabolic profiles of WT and LKO mice fed a high-fat diet.
| WT |
LKO |
|||
|---|---|---|---|---|
| Con | Celastrol | Con | Celastrol | |
| Serum TG (mg/dL) | 278.9 ± 19.46 | 228.7 ± 4.226* | 141.7 ± 16.08 | 135.8 ± 5.197 |
| Serum TC (mg/dL) | 191.3 ± 14.46 | 184.2 ± 8.969 | 144.4 ± 10.24 | 151.5 ± 7.038 |
| Serum FFA (mg/dL) | 1.390 ± 0.0715 | 1.091 ± 0.0498** | 1.073 ± 0.0692 | 1.039 ± 0.0740 |
| Serum ALT (U/L) | 84.06 ± 8.813 | 50.94 ± 3.084** | 68.25 ± 7.170 | 62.58 ± 14.84 |
| Serum AST (U/L) | 167.6 ± 11.01 | 160.8 ± 6.589 | 176.1 ± 8.902 | 136.6 ± 18.89 |
| Liver TG (mg/g liver) | 140.9 ± 14.03 | 88.30 ± 11.44* | 133.4 ± 7.181 | 182.9 ± 5.495** |
| Liver TC (mg/g liver) | 8.017 ± 0.2653 | 8.564 ± 0.5792 | 9.618 ± 0.5686 | 11.29 ± 0.9825 |
The data are presented as the mean ± SEM. (n = 6-8 per group), ∗ p < 0.05, ∗∗ p < 0.001, compared with the control group.