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. 2016 Nov 23;6(1):14–21. doi: 10.1016/j.molmet.2016.11.008

Figure 2.

Figure 2

Fgf21 participates in fructose-mediated induction of ChREBP and DNL. A) HFrD diet mediated induction of hepatic ChREBPβ and its transcriptional targets are diminished in FGF21 KO mice. B) Circulating glucose levels are lower in FGF21 KO mice consuming HFrD. C) Attenuated induction of multiple enzymes regulating DNL in the livers of HFrD fed FGF21 KO mice. (A–B, WT Chow & FGF21 KO Chow n = 5/group, WT HFrD & FGF21 KO HFrD n = 7/group) D) In vivo rates of DNL are reduced in FGF21 KO mice (WT Chow n = 4, FGF21 KO Chow n = 5, WT HFrD & FGF21 KO HFrD n = 6/group). VLDL secretion is attenuated in FGF21 KO mice consuming E) HFrD (WT HFrD n = 8, FGF21 KO HFrD n = 9) and F) Chow diet (WT Chow n = 5, FGF21 KO Chow n = 5). This is, in part, underscored by G) reduced expression of enzymes regulating VLDL assembly (WT Chow & FGF21 KO Chow n = 5/group, WT HFrD & FGF21 KO HFrD n = 7/group). Taken together these impairments lead to a net reduction in H) hepatic triglyceride content. Data are shown as the mean ± SEM. *P < 0.05, Chow vs Fructose for each genotype. #P < 0.05, Fructose WT vs Fructose KO.