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. 2004 Oct 5;101(41):14913–14918. doi: 10.1073/pnas.0406282101

Fig. 4.

Fig. 4.

Serum HBeAg elicits in vivo tolerance/anergy in 7/16-5 T cells. Unprimed spleen cells (5 × 106 per milliliter) of single 7/16-5 TCR-Tg, 7/16-5 × HBc double-Tg, 7/16-5 × HBe double-Tg, or triple-Tg mice were cultured with the indicated panel of HBc/HBeAgs (1.0 μg/ml), and IL-2 and IFN-γ cytokine production was measured in 2- and 4-day culture supernatants, respectively. In vivo IgG anti-HBc serum titers are shown for each mouse. Data are from individual mice and representative of at least three independent experiments.