Table 1.
Overview of the fibromyalgia VBM studies in this meta-analysis.
| Name | Year | Journal | Sample/female | Mean age ± SD | Symptoms duration (years) | Foci number | Main area of foci | Scanner | Statistical threshold | Smoothing kernel (mm) | GM change | Tal or MNI | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | Case | Control | |||||||||||
| Kuchinad | 2007 | J. Neurosci | 10/10 | 10/10 | 52 | 45 | 9.1 ± 6.8 | 5 | Cingulate, insular, medial frontal cortices, parahippocampal gyri | Siemens 1.5 T | p < 0.05 corrected | 10 | ↓ | Tal |
| Schmidt- Wilcke | 2007 | J. Pain | 20/19 | 22/20 | 53.6 ± 7.7 | 50.7 ± 7.3 | 14.4 ± 7.2 | 6 | GM decrease in superior temporal gyrus and post. thalamus; GM increase in OFC, cerebellum, striatum | Siemens 1.5 T | p < 0.05 corrected | 10 | ↑↓ | Tal |
| Wood | 2009 | J. Pain | 30/30 | 20/20 | 42.0 ± 8.4 | 40.1 ± 20.0 | NA | 4 | GM decrease in PCC, ACC, parahippocampal gyri | GE 1.5 T | p < 0.0005 uncorr. | 12 | ↓ | Tal |
| Hsu | 2009 | J. Pain | 29/29 | 29/29 | 42.6 ± 3.7 | 42.2 ± 3.8 | 12.8 ± 8.3 | 0 | No change | GE 3 T | p < 0.05 corrected | 10 | N/A | MNI |
| Fallon | 2013 | Neuroimage Clin. | 16/16 | 15/15 | 38.5 ± 8.5 | 39.4 ± 8.7 | 9.1 ± 6.8 | 4 | GM decrease in pons, precuneus; GM increase in SI | Siemens 3 T | p < 0.05 corrected | 10 | ↑↓ | MNI |
| Ceko | 2013 | Neuroimage Clin. | 14/14 | 13/13 | 55.0 ± 2.9 | 55.4 ± 3.7 | 12.1 ± 9.0 | 14 | GM decrease in bilateral ACC, MPFC, frontal pole, right premotor cortex, VLPFC, right DLPFC, right PCC | Siemens 3 T | p < 0.05 corrected | 8 | ↓ | MNI |
| Ceko | 2013 | Neuroimage Clin. | 14/14 | 15/15 | 42.4 ± 5.9 | 43.1 ± 5.3 | 8.8 ± 7.1 | 9 | GM increase in right VLPFC, putamen/GP/NAc, left insula, putamen | Siemens 3 T | p < 0.05 corrected | 8 | ↑ | MNI |
| Diaz-Piedra | 2015 | Brain Imaging Behav | 23/23 | 23/23 | 41.6 ± 4.4 | 39.7 ± 5.4 | 8.6 ± 6.3 | 2 | GM decrease in l' Frontal Med/Sup Orb; GM increase in l' Temporal Pole | Phillips 3 T | p < 0.05 corrected | 8 | ↑↓ | MNI |