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In vivo treatment with DMC corrects the downregulation of P-eNOS expression and the upregulation of COX-2 in the renal arteries isolated from vehicle-treated SHR. Western blot assay reveals decreased P-eNOS (Ser1177) expression and elevated COX-2 expression, which were corrected by DMC treatment for 3 weeks ((a)-(b)). Data are means ± SEM of 5-6 experiments. ∗ P < 0.05 versus WKY; # P < 0.05 SHR + vehicle.
