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. 2016 Dec 25;2016:9045736. doi: 10.1155/2016/9045736

Figure 5.

Figure 5

Combined exposure to DMC prevents Ang II-induced vascular dysfunction in the renal arteries from WKY, with normalization of increased COX-2 expression. Ang II (100 nmol/L, 12 hours) results in impaired relaxations to ACh and unmasked contractions to ACh in the renal arteries from WKY rats ((a) and (c)). Combined administration of DMC (10 µmol/L) rescued the impaired vascular function and COX-2 inhibitor celecoxib offered similar protection ((b) and (d)). The overexpression of COX-2 by Ang II was also reversed by coincubation with DMC (e). Data are means ± SEM of 5-6 experiments. ∗ P < 0.05 versus control; # P < 0.05 versus Ang II.