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The effect of DMC treatment on nitric oxide generation in HUVECs Ang II (1 µmol/L) treatment for 12 hrs reduced the A23187-evoked NO production (a). Cotreatment with DMC, losartan or celecoxib restored the NO generation ((b)-(c)). Consistently, P-eNOS expression was downregulated in 12 hrs-Ang II-treated cells, which was reversed in the presence of DMC, losartan, or celecoxib (d). Data are means ± SEM of 5-6 experiments. ∗ P < 0.05 versus control; # P < 0.05 versus Ang II.
