Table 3.
Reactions carried out by the human CYP1A1 depending on the type of substrate.
| Origin | Category compound | Type of reaction | Source |
|---|---|---|---|
| Synthetic compounds | Polycyclic aromatic hydrocarbons | Oxidation Epoxidation | [80, 81] |
| Nitrosamides | Nitroreduction | [82, 83] | |
| Arylamines | N-hydroxylation Oxidation | [80, 81] | |
| Benzotriazole | Oxidation | [84] | |
| Heterocyclic amines | N-hydroxylation Oxidation | [80, 81] | |
| Nitroarenes | Nitroreduction | [85] | |
| Azoaromatic amines | Oxidation | [80, 81] | |
|
| |||
| Natural compounds | Difuranocumarin | Epoxidation Oxidation | [86] |
| Nefrotoxin | Hydroxylation | [87] | |
| Flavonoid | Hydroxylation O-demethylation | [88, 89] | |
|
| |||
| Drugs | Ellipticin | Oxidation | [90] |
| Omeprazol | ND | [91] | |
| Oltipraz | ND | [92] | |
|
| |||
| Endogenous substrates | Arachidonic acid | Hydroxylation | [93] |
| Melatonin | Hydroxylation | [94] | |
| Eicosapentaenoic acid | Epoxidation | [93] | |
| Stradiol | Hydroxylation | [95] | |