Table 2.
Correlation of the resected lung adenocarcinoma classification (n = 87) with clinical characteristics.
| Variable | Category | AIS and MIA (n = 41) |
IAC (n = 46) |
P value |
|---|---|---|---|---|
| Sex | Male | 15 (36.6) | 23 (50.0) | 0.279 |
| Female | 26 (63.4) | 23 (50.0) | ||
|
| ||||
| Median age (years) | 52.8 ± 10.3 | 62.7 ± 9.8 | <0.001∗ | |
|
| ||||
| Smoking | Always smoked | 33 (80.5) | 33 (71.7) | 0.453 |
| Never smoked | 8 (19.5) | 13 (28.3) | ||
|
| ||||
| Radiological finding | Pure GGO | 18 (43.9) | 1 (2.2) | <0.001∗ |
| Mixed GGO | 23 (56.1) | 28 (60.9) | ||
| Pure solid nodule | 0 | 17 (36.9) | ||
|
| ||||
| CEA [IQR (median)] (ng/mL) | 1.17–2.32 (1.78) | 1.48–4.31 (2.30) | 0.015∗ | |
|
| ||||
| Serum miR-183 [IQR (median)] | 0.232–1.63 (0.790) | 0.684–4.33 (1.325) | 0.042∗ | |
|
| ||||
| Tumour size | ≤10 mm | 36 (87.8) | 6 (13.0) | <0.001∗ |
| >10 to ≤20 mm | 4 (9.8) | 26 (56.5) | ||
| >21 to ≤30 mm | 1 (2.4) | 14 (30.5) | ||
|
| ||||
| Lymph node metastasis | Absent | 41 (100.0) | 42 (91.3) | 0.119 |
| Present | 0 | 4 (8.7) | ||
|
| ||||
| Visceral pleural invasion | Absent | 41 (100.0) | 37 (80.4) | 0.003∗ |
| Present | 0 | 9 (19.6) | ||
|
| ||||
| Pathological stage | 0/IA | 40 (97.6) | 30 (65.2) | <0.001∗ |
| IB/IIA/IIB/IIIA | 1 (2.4) | 16 (34.8) | ||
∗Statistically significant p value
CEA, carcinoembryonic antigen; GGO, ground-glass opacity; IQR, interquartile range; AIS, adenocarcinoma in situ; MIA, minimally invasive adenocarcinoma; IAC, invasive adenocarcinoma.