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| Dose (mg/kg) | Compound 48/80 (8 mg/kg) | Mortality (%) |
|---|---|---|
| None (saline) | + | 100 |
| o-VA 1 | + | 40 |
| 10 | + | 30 |
| 100 | + | 20 |
| 100 | − | 0 |
| Dexa 10 | + | 20 |
Mice were given an intraperitoneal injection of 8 mg/kg of mast cell degranulator, compound 48/80. o-VA was orally administered at doses of 1, 10, and 100 mg/kg 1 h before the injection of compound 48/80 (n=10/group). Mortality was monitored for 1 h after induction of anaphylactic shock.
