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. 2016 Oct 24;38(1):69–79. doi: 10.1038/aps.2016.119

Figure 3.

Figure 3

Effects of AB23A on the hepatic expression of proteins or genes involved in triglyceride and fatty acid synthesis and metabolism. (A) The expression of proteins involved in triglyceride and fatty acid synthesis, including SREBP-1c, FAS, ACC1 and SCD1 was increased by the MCD diet and was reduced by AB23A treatment. Data are the mean±SD. n=5. *P<0.05 vs control. #P<0.05 vs MCD+vehicle. AB23A increased the gene expression of CPT1α, ACADS and PPARα, which are involved in fatty acid β-oxidation (B). AB23A also increased the lipolysis of triglyceride-rich lipoproteins through regulating the gene expression of Apo C-II, Apo C-III, ANGPTL3 and LPL (C). Data are the mean±SD. n=5. *P<0.05 vs control. #P<0.05 vs MCD+vehicle.