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. 2016 Oct 24;38(1):69–79. doi: 10.1038/aps.2016.119

Figure 5.

Figure 5

Effects of AB23A on the regulation of proteins and genes involved in lipid homeostasis are abrogated by the FXR antagonist GS. (A) The hepatic expression of SREBP-1c, FAS, ACC1 and SCD1 in mice treated with vehicle, AB23A, the FXR antagonist, GS or GS+AB23A. (B) Changes in expression of PPARα, CPT1α, ACADS and LPL in AB23A-treated mice were abrogated by GS. Data are the mean±SD. n=5. *P<0.05 vs MCD only. #P<0.05 vs MCD+AB23A. (C) Representative images of H&E stained liver sections (400×magnification) after GS administration are shown.